IMMUSYNC™

IMMUSYNC is effective in balancing the immune system of the body against any foreign attacks or internal stimulus to the immune system because of the collective immunity-boosting properties of the medicinal herbs used as ingredients in the formulation. Below are the mechanisms of how these herbs are acting on our immune system.

GUDUCHI: Guduchi (Tinospora cordifolia), also known as Giloy, is referred to as “Amrit” in Sanskrit, meaning “divine nectar.” It is highly valued in Ayurveda for its detoxifying, rejuvenating, immune-boosting, and anti-rheumatic properties. Guduchi enhances the phagocytic activity of macrophages and production of reactive oxygen species (ROS) in human neutrophil cells(1). It also increases proinflammatory cytokines such as IL-1β, IL-6, TNF-α, granulocyte-monocyte-colony-stimulating factor (GM-CSF).

ASHWAGANDHA:Inflammation is a complex immunological process. The initial acute stage of inflammation is mediated through the activation of immune cells, the resultant inflammatory cytokines and intracellular pathways such as Nf-kB. Withanolides, the active constituent of Ashwagandha, inhibits NF-κB activation and block the expression of LPS- or TNFα-induced NF-κB-regulated inflammatory genes such as iNOS, COX-1, COX-2 and NO. The extract selectively induces type 1 immunity because it helps enhanced expression of T helper cells (Th1)- cytokine interferon (IFN-gamma) and interleukin (IL-2) while Th2 cytokine IL-4 declines moderately (2).

TURMERIC: Curcumin (20% curcumin in one IMMUSYNC tablet) is the active constituent of a Rasayan drug Turmeric and has high safety and low toxicity profile. Infections from viruses such as avian influenza, dengue, and coronavirus can lead to cytokine storms, producing a massive amount of pro-inflammatory cytokines. The collective action of these inflammatory mediators causes the destruction of tissues and cells in the lungs and other organs, and the clinical syndromes are extensive pulmonary edema, alveolar hemorrhage, ARDS, and multiple organ failures, etc. Evidence from preclinical studies demonstrates that it inhibits viral infection, alleviates the severity of lung injury through offsetting the cytokine storm, inhibits subsequent fibrosis, and increases survival rates (3).

TULSI:Tulsi is rich in Vitamin C and zinc. It has been studied that the extract of Tulsi leaves increases the T helper cells and natural killer cells activity and boosts the immune system. Active compounds such as Camphene, cineole, and eugenol present in Tulsi extract help to reduce cold and congestion in the chest. Ocimumosides A and B, present in Tulsi leaves, reduce stress and effectively boost the immunity, also balance the neurotransmitters serotonin and dopamine in the brain. It is also observed that it inhibits replication of Coronavirus supported with its immune-modulatory feature and ACE II blocking properties. Tulsinol (A, B, C, D, E, F, G) and dihydrodieuginol-B, present in leaves of Tulsi, also inhibit SARS Coronavirus Main Protease and Papain-like Protease (4).

SUNTHI:The active components of Ginger rhizome gingerols, shagaols, and paradols, etc., inhibit prostaglandin and leukotriene biosynthesis, inhibit cyclooxygenase and lipoxygenase activities, and inhibit the synthesis of pro-inflammatory cytokines such as IL-1, TNF-α, and IL-8 without any significant effect on IL-6 levels.

BLACK PEPPER:Black Pepper regulates the balance of the cytokines production of Th1, Th2, Th17, and Treg cells, reduces the accumulation of inflammatory cells, inhibits the expressions of pro-inflammatory cytokines (IL-4, IL-6, IL-1β, IL-17A) and TNF-α, increases INF-γ and IL-10 secretions in the respiratory tract, and increases macrophage activation and T and B cell proliferation.