CAUTION: SCHEDULE E-1 DRUG. TO BE TAKEN UNDER MEDICAL SUPERVISION
Cannapain+®capsule is an ayurvedic proprietary medicine and is formulated from CBD oil. CBD oil Is a cannabis leaf derived Product. CBD oil contains various active compounds like cannabinoid, terpenes, flavonoids and pigments etc. and all of which have a significant therapeutic effect on a wide range of symptoms and disease. CBD (Cannabidiol) is also one of the therapeutic potential cannabinoids found in the cannabis plant.
Cannapain+® is an ideal cannabis-based formulation for alleviating various kinds of aches and pain. It is effective in arresting neuropathic pain like sciatica and trigeminal neuralgia, conditions that affect mobility. This medicine is especially efficacious for muscular spasm. Cannapain keeps you active throughout the day by reducing fatigue. It also enhances appetite and quality of sleep. It helps calm your nerves by diminishing the intensity of anxiety.
This medicine is FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals.
Chronic Pain/ Neuropathic pain/ Sciatica: It is evident from research that cannabinoids such as THC and CBD in 1:1 ratio produce analgesia by acting on multiple pain targets within the peripheral and CNS along with the activation of CB1 and CB2 receptors. They may reduce pain through interaction with the putative non-CB1/CB2 cannabinoid G protein-coupled receptors (GPCR55 or GPCR18)and opioid or serotonin (5-HT) receptors (1). A 1:1 ratio of CBD:THC has been found effective for chronic pain(2) and chemotherapy induced neuropathic pain (3).
CINV (Chemotherapy Induced Nausea and Vomiting): Acute CINV occurs within 24 hours of initiating chemotherapy and mainly involves receptors in the GI tract and is primarily mediated by activation of receptors in the brain. THC (delta(Δ)9-tetrahydrocannabinol) binds to cannabinoid receptors CB1 & CB2 that are located throughout the body, including in the brain (CB1) and the immune system (CB2). Activation of CB1 by THC can have medically desirable effects, such as decreasing the incidence of nausea and vomiting. The addition of CBD (Cannabidiol) to THC should ameliorate the intoxicating effects of THC, and allow delivery of higher therapeutic doses, without increasing the overall intoxication, paranoia and euphoria associated with THC, with diminished potential for abuse (4).
Anxiety & Depression: CB1 and lower peripheral concentrations of anandamide or N-arachidonoylethanolamine (AEA), the endogenous ligand of CB1, is involved in the pathophysiology of anxiety, and activation of CB1 and increased concentration of THC (structurally similar to anandamides) and CBD (Structurally similar to AEA) appears to be inversely correlated to symptoms of anxiety and depression (5).
Appetite loss: Appetite signal is passed to brain by a hormone called ghrelin. Insufficient release of this hormone is the main cause of appetite loss. This medicine triggers a ghrelin surge and stimulates appetite (6).
Seizures: A seizure happens when the brain’s electrical activity becomes deregulated and all the neurons fire repeatedly at the same time. Activation of CB1 receptor controls the firing of neurons and thus helps in controlling seizures (7).