CAUTION: SCHEDULE E-1 DRUG. TO BE TAKEN UNDER MEDICAL SUPERVISION
Cannapain® capsule is an ayurvedic proprietary medicine and is formulated from CBD oil. CBD oil Is a cannabis leaf derived Product. CBD oil contains various active compounds like cannabinoid, terpenes, flavonoids and pigments etc. and all of which have a significant therapeutic effect on a wide range of symptoms and disease. CBD (Cannabidiol) is also one of the therapeutic potential cannabinoids found in the cannabis plant.
Cannapain® is an ideal cannabis-based formulation for alleviating various kinds of aches and pain. It is effective in arresting neuropathic pain like sciatica and trigeminal neuralgia, conditions that affect mobility. This medicine is especially efficacious for muscular spasm. Cannapain keeps you active throughout the day by reducing fatigue. It also enhances appetite and quality of sleep. It helps calm your nerves by diminishing the intensity of anxiety.
This medicine is FREE from chemicals, artificial flavors or sweeteners, sugar, salt, gluten, soy, pesticides and heavy metals.
Chronic Pain/ Neuropathic pain/ Sciatica: It is evident from research that cannabinoids such as THC and CBD in 1:1 ratio produce analgesia by acting on multiple pain targets within the peripheral and CNS along with the activation of CB1 and CB2 receptors. They may reduce pain through interaction with the putative non-CB1/CB2 cannabinoid G protein-coupled receptors (GPCR55 or GPCR18)and opioid or serotonin (5-HT) receptors (1). A 1:1 ratio of CBD:THC has been found effective for chronic pain(2) and chemotherapy induced neuropathic pain (3).
CINV (Chemotherapy Induced Nausea and Vomiting): Acute CINV occurs within 24 hours of initiating chemotherapy and mainly involves receptors in the GI tract and is primarily mediated by activation of receptors in the brain. THC (delta(Δ)9-tetrahydrocannabinol) binds to cannabinoid receptors CB1 & CB2 that are located throughout the body, including in the brain (CB1) and the immune system (CB2). Activation of CB1 by THC can have medically desirable effects, such as decreasing the incidence of nausea and vomiting. The addition of CBD (Cannabidiol) to THC should ameliorate the intoxicating effects of THC, and allow delivery of higher therapeutic doses, without increasing the overall intoxication, paranoia and euphoria associated with THC, with diminished potential for abuse (4).
Anxiety & Depression: CB1 and lower peripheral concentrations of anandamide or N-arachidonoylethanolamine (AEA), the endogenous ligand of CB1, is involved in the pathophysiology of anxiety, and activation of CB1 and increased concentration of THC (structurally similar to anandamides) and CBD (Structurally similar to AEA) appears to be inversely correlated to symptoms of anxiety and depression (5).
Appetite loss: Appetite signal is passed to brain by a hormone called ghrelin. Insufficient release of this hormone is the main cause of appetite loss. This medicine triggers a ghrelin surge and stimulates appetite (6).
Seizures: A seizure happens when the brain’s electrical activity becomes deregulated and all the neurons fire repeatedly at the same time. Activation of CB1 receptor controls the firing of neurons and thus helps in controlling seizures (7).
MECHANISM OF ACTION
Endocannabinoid system is a collection of neuromodulators (endocannabinoids), their receptors (CB1 & CB2) and signaling pathways in our body. It regulates the body’s physiological system to maintain homeostasis (the state of balance). Phyto-cannabinoids (CBD & THC) bind mainly to CB1 and CB2 receptors and specific enzymes & metabolites to activate the pathways and regulate the symptoms.
This is made using full-spectrum cannabis extract infused in coconut oil. The high grade organic coconut oil boosts the absorption of cannabinoids because it allows easy absorption in the digestive tract and metabolism in liver. Infusion of cannabinoids in coconut oil thus boosts the bioavailability of cannabinoids and helps in breaking down the cannabinoid-coconut oil complex in liver for immediate effect.
- Vučković S. et al. Cannabinoids and Pain: New Insights From Old Molecules. Frontiers in pharmacology, 2018, 9: 1-19. 59
- Wilsey BL.et al., A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis. J. Pain Res., 2016, 9: 587–598.
- Wilsey BL. et al., Low-dose vaporized cannabis significantly improves neuropathic pain. J. Pain., 2013. 14: 136–148
- Badowski ME., A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics. Cancer Chemother Pharmacol., 2017, 80(3):441–449.
- Kamal B.S. et al., Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype. Frontiers in Neuroscience, 2018, 12: 730.
- Society for the Study of Ingestive Behavior. "How cannabis affects appetite: Brain changes." Science Daily, 17 July 2018.
- Reddy DS. & Golub VM., The Pharmacological Basis of Cannabis Therapy for Epilepsy. J Pharmacol Exp Ther., 2016, 357:45–55.
HPMC veg capsule filled with 125mg Cannabis leaves wholesome extract, organic cold pressed coconut oil and ginger oil.
*100% Plant derived| Cruelty free| Gluten free| Chemical free| Free from synthetic fillers|
SIDE EFFECTS & SAFETY
Cannapain® is LIKELY SAFE when taken orally as a prescription medication. Some reported side effects of Cannabis include dry mouth, decrease in blood pressure, increased heartbeat, light-headedness, and drowsiness.
PRECAUTIONS & WARNING
Allergy: DO NOT take this medicine if you are allergic to Cannabis or any of the ingredients contained in this drug.
Pregnancy: Breast feeding mothers and pregnant women should take Cannapain® strictly under Doctor's supervision and guidance.
Heart disease: It might increase heartbeat, and fluctuations in blood pressure. Patients suffering from heart diseases should take this under strict Doctor’s guidance and supervision.
Surgery: It might slow down the effect of anesthesia when combined with anesthesia and other medications during and after surgery. Stop taking it at least 2 weeks before a scheduled surgery.
Keep away from Children.
DO NOT drive or operate any machine while under Cannabis medication.
DO NOT take Alcohol while under Cannabis medication.
Taking Cannapain® is LIKELY SAFE and can be taken with most drugs. However, it is best to consult your doctor before starting and sharing the list of all medications to find out drug interactions.
Drugs for Sedative medications (Barbiturates & CNS depressants): Taking Cannapain® along with sedative medications might cause too much sleepiness. With fluoxetine, it might cause you to feel irritated, nervous, jittery and excited. Doctors call this hypomania.
Drugs for Alcohol de-addiction: Taking Cannapain® along with drugs for alcohol de-addiction i.e., Disulfiram can cause agitation, trouble sleeping and irritability.
Drugs that control blood sugar level: No conclusive evidence found for such kind of drug interaction. However it is considerably safe to take with drugs that control blood sugar level.
This drug can also interact with Astemizole, Cisapride, Pimozide & Terfenadine. So it is advisable not to take Cannapain® with these drug combinations.
It is advisable to start with low dose as dosage may vary according to disease state and conditions. Dose may also vary from person to person depending on a person’s tolerance level. It is best to follow a physician’s advice to find the right dose.
Frequently asked questions about cannabis Medicines / Hemp Medicines
Question: what is cannabis medicines?
Answer: Medicinal Cannabis means the cannabis plant or its extract or chemical is used for medicinal purpose for treating several diseases. The Cannabis plant contains more than 100 different chemicals called phyto-cannabinoids. All Phytocannabinoids have different medicinal effects on body. However Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the main chemicals which are highly potential in treating diseases.
Question: What is Cannabinoids?
Answer: Cannabinoids are the active constituents in cannabis plant and are similar to chemicals the body makes (called endocannabinoids) that are involved in appetite, memory, mood, movement and pain.
Question: What medicine contains cannabinoids?
Answer: Cannabinoids are the active constituents present in cannabis plant. Medicines like Cannapain and Cannaflam are made up of Cannabis leaf extract which contains cannabinoids.
Question: Who can take cannabis oil or oil capsules?
Answer: Anyone above age 18+ can take these medicines but strictly under the Doctor’s supervision.
Question: Side effect of cannabis medicines and cannabis oil?
Answer: Cannabis oil is generally well tolerated and considered safe to consume. However some common and mild side effects occur such as drowsiness, gastrointestinal issues, dry mouth and the event of occurrences of side effects are very rare.
Question: Is cannabis medicine available in India?
Answer: Cannabis medicine in India is now gaining popularity because of its effectiveness. HempCann Solutions manufactures Ayurvedic cannabis medicines in India.
Cannabis Infused Products- : Ayurvedic classical and proprietary medicines such as Kameswar Modaka, Jatiphaladi churna, Bilvadi Churna, Sarpagandha ghanvati, Cannaflam, Cannapain etc are mainly cannabis infused products, where Cannabis leaves is one of the major ingredients.
Buy hemp Products – : Hemp products such hemp seeds, hemp seed oil, etc. are available in India on various online platform. Hemp medicines manufactured by Hempcann Solutions are available online at Vedi.
Buy Cannabis Products – Medical Cannabis Products such as Sarpagandha ghanvati, Kameswar modaka, Jatiphaladi, Bilvadi and proprietary cannabis medicines such as Cannapain and Cannaflam are manufactured by Hempcann solutions and are available online at Vedi.
Medical Marijuana Products in India – : In India marijuana Is basically used as medicine as processed bhang and bhang containing ayurvedic medicines. According to ayurveda, Bhang is used in more than 200 formulations for treating Various Diseases.